| 生化机理 |
Description:
IC50 Value: 1.1uM (Cytotoxicity in the CCLP-1 cell line) [1]
FH535 is a compound that suppresses both Wnt/beta-catenin and peroxisome proliferator-activated receptor (PPAR) signaling. FH535antagonizes both PPAR gamma and PPAR delta ligand-dependent activation and shows structural similarity to GW9662, a known PPAR gamma antagonist.
in vitro: FH535 significantly inhibited cell migration of Mel 1241 cells, which was associated with the elevated levels of casein kinase 1α and glycogen synthase kinase-3β, and decreased accumulation of nuclear β-catenin and inhibition of MMP-2 and MMP-9 levels [2]. FH535 was shown to increase CSC-induced cytotoxicity and depress β-catenin expression. However, FH535 effects were not limited to the β-catenin pathway as it also blocked the expression of early growth responsive protein 1 (EGR-1) target genes, fibronectin and phosphatase and tensin homologue, without affecti |
