| 应用 |
An inhibitor of NKCC and a GABAA receptor antagonist.Furosemide may also be used as a reference standard in determining the concentration of furosemide present in human urine samples using gas chromatography coupled with mass spectrometry (GC-MS). Furosemide may be used pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using diffuse reflectance spectroscopy.
Furosemide may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by fluorimetry, spectrophotometry and high performance liquid chromatography (HPLC).
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. |
| 产品介绍 |
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Furosemide is a diuretic drug, which finds a variety of therapeutic applications such as hepatic cirrhosis, cardiac insufficiency and arterial hypertension.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Furosemide is classified under the group of loop diuretics. It is used for the prevention of hypertension linked to renal and cardiac insufficiency. |
| 备注 |
Furosemide(Lasix) is a loop diuretic used in the treatment of congestive heart failure and edema. |
| 生化机理 |
Furosemide is a loop diuretic inhibitor of NKCC (Na+/2Cl-/K+) cotransporter. Furosemide acts as a non-competitive antagonist at GABAA receptors with ~ 100-fold greater selectivity for α6-containing receptors than α1-containing receptors. |
| 别名 |
呋噻米;速尿;呋喃苯胺酸;利尿磺胺;4-氯-N-呋喃基-5-氨磺酰邻氨基苯甲酸;5-(氨基磺酰基)-4-氯-2-([2-呋喃甲基]氨基)苯甲酸;2-(2-呋喃甲基)氨基-5-(磺酰氨基)-4-氯苯甲酸;4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid; 5-(Aminosulfonyl)-4-chloro-2-([2-furanylmethyl]amino)benzoic acid;Frusemide; Lasix; Furanthril; Errolon; Fusid; Fuluvamide; Furanthryl; Furantril; Furosemid |
