| 应用 |
An androgen receptor inhibitor |
| 产品介绍 |
Enzalutamide (MDV3100)是一种雄激素受体(AR)拮抗剂，IC50为36 nM。 |
| 生化机理 |
MDV3100 is an androgen receptor inhibitor and antagonizes induction of prostate-specific antigen (PSA) and transmembrane serine protease 2 (TMPRSS2) in combination with the synthetic androgen R1881 in parental LNCaP cells. MDV3100 prevents nuclear translocation and co-activator recruitment of the ligand-receptor complex |
| 别名 |
MDV3100;MDV-3100; MDV 3100;恩扎鲁胺;恩杂鲁胺;4-[3-[4-氰基-3-(三氟甲基)苯基]-5,5-二甲基-4-氧代-2-硫酮-1-咪唑烷基]-2-氟-N-甲基苯甲酰胺;MDV3100;MDV-3100; MDV 3100;4-[3-[4-Cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]-2-fluoro-N-methylbenzamide |
