Eltrombopag

属性

溶解性	25°C: DMSO 89 mg/mL; Water <1 mg/mL; Ethanol <1 mg/mL
存贮条件	储存温度-20°C

描述

应用	An agonist of the thrombopoietin receptor
产品介绍	Eltrombopag 是小分子，c-mpl (TpoR) 受体激动剂，抑制 hERG K+通道尾电流，IC50为0.69 μM。
备注	Eltrombopag is a small molecule agonist of the c-mpl (TpoR) receptor with an IC50 of 0.69 μM for the inhibition of hERG K+ channel tail current.
生化机理	An agonist of the Thrombopoietin (Tpo) receptor, used as treatment for thrombocytopenia.
别名	SB-497115-GR, Revolade, Promacta;伊屈泼帕; 3'-[2-[(2Z)-1-(3,4-二甲基苯基)-1,5-二氢-3-甲基-5-氧代-4H-吡唑-4-亚基]肼基]-2'-羟基-[1,1'-联苯]-3-羧酸;SB-497115;SB-497115-GR;SB497115;SB 497115;Promacta;3'-[2-[(2Z)-1-(3,4-Dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazinyl]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid