| 应用 |
An antifungal compound and CYP inhibitor |
| 产品介绍 |
Clotrimazole是一种合成的抗真菌药物，是imidazole的广谱衍生物 |
| 备注 |
Clotrimazole is a synthetic, antifungal and broad-spectrum derivate of imidazole. |
| 生化机理 |
Clotrimazole is an imidazole derivative and an antifungal compound and a CYP (cytochrome P450) inhibitor. Clotrimazole has been shown to block the intermediate-conductance, IK1 channels (Ca2+ activated K+ channels), in cells such as erythrocytes. In vitro studies of various yeast strains have demonstrated susceptibility to clotrimazole. Clotrimazole is an activator of MB67 and an inhibitor of CYP3A4 and CYP51A1. |
| 别名 |
1-[(2-氯苯基)二苯甲基]-1H-咪唑;三苯氯甲咪唑;氯苯甲咪唑;克霉唑;1-[(2-氯苯基)二苯甲基]咪唑;1-(2-氯三苯甲基)咪唑;1-[(2-Chlorophenyl)diphenylmethyl]-1H-imidazole;1-(o-Chlorotrityl)imidazole ;1-[(2-Chlorophenyl)diphenylmethyl]imidazole ;1-(2-Chlorotrityl)imidazole |
