货号 | CAS号 |
---|---|
C126954-50mg | 728865-23-4 |
C126954-5mg | 728865-23-4 |
C126954-10mg | 728865-23-4 |
溶解性 | DMSO |
存贮条件 | 储存温度-20°C |
生化机理 |
The UDP-3-O-(R-3-hydroxyacyl)-N-acetylglucosamine deacetylase LpxC is an essential enzyme of lipid A biosynthesis in Gram-negative bacteria and a promising antibiotic target. CHIR-090 is a potent LpxC inhibitor, displays two-step time-dependent inhibition and kills a wide range of Gram-negative pathogens as effectively as ciprofloxacin or tobramycin. |