BMS-378806-分析测试百科网

溶解性	DMSO 81 mg/mL Water <1 mg/mL Ethanol 3 mg/mL
存贮条件	储存温度-20°C

备注	BMS-378806 selectively inhibits the binding of HIV-1 gp120 to the CD4receptor with EC50 of 0.85-26.5 nM in virus.
生化机理	BMS-806 (BMS 378806) is a small molecule gp120/CD4 inhibitor with an IC50 of median 5 nM. BMS-806 (BMS 378806) was proved to be specific for HIV-1, with no activity against HIV-2 or simian immunodeficiency virus. BMS-806 (BMS 378806) is active against HIV-1 isolates irrespective of chemokine receptor preference. BMS-806 (BMS 378806) binds gp120, and changes in particular gp120 amino acid residues can alter the sensitivity of the virus to BMS-806 (BMS 378806). BMS-806 (BMS 378806) potently inhibited HIV-1 infection regardless of the particular chemokine receptor used.
别名	(R)-1-(4-benzoyl-2-methylpiperazin-1-yl)-2-(4-methoxy-7H-pyrrolo[2,3-b]pyridin-3-yl)ethane-1,2-dione;(R)-1-(4-benzoyl-2-methylpiperazin-1-yl)-2-(4-methoxy-7H-pyrrolo[2,3-b]pyridin-3-yl)ethane-1,2-dione