| 应用 |
A competitive inhibitor of HMG-CoA reductase |
| 产品介绍 |
Pitavastatin Calcium is a competitive inhibitor of the enzyme HMGCR (HMG-CoA reductase) results in a reduction in LDL cholesterol synthesis. Alternate studies show that pitavastatin can suppress oxygen production in endothelial cells by inhibiting NADPH oxidase. In addition, pitavastatin reduces the expression of eNOS mRNA while increasing the NO dependent response stimulated by acetylcholine and the calcium ionophore, A23187. Furthermore, pitavastatin inhibits the up-regulation of conductance calcium-activated potassium channels by lowering cholesterol levels in cells. |
| 备注 |
Pitavastatin calcium (Livalo) is a novel member of the medication class of statins. |
| 生化机理 |
Pitavastatin Calcium 是一种新型的Statins类药物。 |
| 别名 |
匹伐他汀钙; (+)-双{(3R,5S,6E)-7-[2-环丙基-4-(4-氟代苯基)喹啉-3-基]-3,5-二羟基-6-庚烯酸}钙盐 (2:1);Pitavastatin hemicalcium; Nisvastatin;(+)-Monocalcium bis{(3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-3,5-dihydroxy-6-heptenoate} |
