Pamidronate disodium salt hydrate

属性

溶解性	DMSO <1 mg/mL Water 56 mg/mL Ethanol <1 mg/mL
存贮条件	储存温度 2-8°C

描述

应用	A farnesyl diphosphate synthase inhibitor.
生化机理	Pamidronate disodium salt is a bisphosphonate compound, which inhibits farnesyl diphosphate synthase and bone resorption. Studies suggest that Pamidronate disodium salt stimulates polymorphonuclear leukocyte and platelet derived nitric oxide production. It is believed that this nitric oxide production can lead to a negative feedback mechanism, which could restrict the inflammatory process and reduce bone resorption. Furthermore, bisphosphonates induce endothelial cell death, cancer cell apoptosis, and nuclear factor-κB pathway activation, via the endothelial protein C receptor.
别名	帕米膦酸钠水合物; 3-氨基-1-羟基丙亚基-1,1-二磷酸二钠水合物;Aredia;3-Amino-1-hydroxypropane-1,1-diphosphonic acid disodium salt