Pioglitazone

属性

溶解性	Soluble in water (<1 mg/ml at 25 °C), DMSO (15 mg/ml at 25 °C), DMF (2.5 mg/ml), ethanol (<1 mg/ml at 25 °C), and 1:1 solution of DMSO:PBS (pH 7.2) (~ 0.1 mg/ml).
存贮条件	储存温度-20°C

描述

应用	A PPAR agonist with potential antidiabetic characteristics.
产品介绍	Pioglitazone 是一种选择性过氧化物酶体增殖物激活受体γ激动剂。
备注	Pioglitazone (Actos) is a selective peroxisome proliferator-activated receptor gamma stimulator.
生化机理	Pioglitazone, a thaizolidinedione derivative, has been shown to be a high affinity ligand for the peroxisome proliferator-activated receptor (PPAR), specifically PPARγ1 and PPARα activator. Binding assays have indicated that this activation is due to direct binding of pioglitazone to each subtype. It has been noted that this agent promotes adipocyte differentiation of mesenchymal and preadipocyte stem cell lines In vitro. Additionally, pioglitazone is an inhibitor of NF κB.
别名	匹格列酮; 5-[[4-[2-(5-乙基吡啶-2-基)乙氧基]苯基]甲基]-1,3-噻唑烷-2,4-二酮;Glustin; U 72107; Zactos;5-[[4-[2-(5-Ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione