| 应用 |
An epigenetic chemical probe. |
| 产品介绍 |
PFI-1能阻断BET BRDs与H3、H4乙酰化组蛋白尾巴的相互作用。 |
| 生化机理 |
The human BET family, which includes BRD2, BRD3, BRD4 and BRDT, play a role in regulation of gene transcription. PFI-1 is a selective BET bromodomain inhibitor with activity at BRD2 (IC50 = 98 nM) and BRD4 (IC50 = 220 nM). For full characterization details, please visit the PFI-1 probe summary on the Structural Genomics Consortium (SGC) website. |
| 别名 |
PFI-1；PFI 1;PFI1；2-甲氧基-N-(3-甲基-2-氧代-1,2,3,4-四氢喹唑啉-6-基)苯磺酰胺;PFI-1；PFI 1;PFI1；PF-06405761；2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide |
