GDC-0980 (RG7422)-分析测试百科网

沸点	~718.6° C at 760 mmHg
熔点	222-226° C
折光率	1.68
溶解性	DMSO 20 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
存贮条件	储存温度-20°C
密度	1******

应用	A PI3K and FRAP (mTOR) kinase inhibitor
产品介绍	GDC-0980 (RG7422)是I型PI3K抑制剂，对PI3Kα，β，δ和γ的IC50分别为5 nM，27 nM，7 nM和14 nM，对mTOR的Ki为17 nM。
备注	GDC-0980 (RG7422) is a potent, class I PI3K inhibitor for PI3Kα/β/δ/γ with IC50 of 5 nM/27 nM/7 nM/14 nM, respectively. Also a mTOR inhibitor with K_i of 17 nM, and highly selective versus others PIKK family kinases.
生化机理	GDC-0980 (RG7422) is a selective, dual PI3 Kinase and mTOR Kinase inhibitor with IC50 of 5, 27, 7, and 14 nM for PI3Kα, β, δ, and γ, respectively.
别名	GNE 390; GDC 0980; RG 7422;(s)-1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno(3,2-d)pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one;GNE 390; GDC 0980; RG 7422; (S)-1-(4-((2-(2-氨基嘧啶-5-基)-7-甲基-4-(吗啉-4-基)噻吩并(3,2-d)嘧啶-6-基)甲基)哌嗪-1-基)-2-羟基丙-1-酮;