GDC-0068-分析测试百科网

溶解性	DMSO 92 mg/mL Water <1 mg/mL Ethanol 92 mg/mL
存贮条件	储存温度-20°C

产品介绍	GDC-0068(RG 7440)是泛Akt抑制剂，对Akt1/2/3的IC50分别为5 nM/18 nM/8 nM，比对PKA的抑制性高620倍。
备注	GDC-0068 is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5 nM/18 nM/8 nM, 620-fold selectivity over PKA. Phase 2.
生化机理	GDC-0068 is a novel, highly selective oral ATP-competitive inhibitor designed to bind to the 3 isoforms of Akt. GDC-0068 is a highly selective pan-Akt inhibitor targeting Akt1, Akt2 and Akt3 with IC50 of 5 nM, 18 nM and 8 nM, respectively. GDC-0068 inhibits the growth and proliferation of cancer cell lines and xenograft models, including those with loss of PTEN function, oncogenic mutations in PIK3CA, and amplification of HER2. Phase I study of GDC-0068 in patients with refractory solid tumors is ongoing.
别名	RG7440; GDC0068; GDC 0068; RG-7440; RG 7440; (2S)-2-(4-氯苯基)-1-(4-((5R,7R)-6,7-二氢-7-羟基-5-甲基-5H-环戊并嘧啶-4-基)-1-哌嗪基)-3-((1-甲基乙基)氨基)-1-丙酮;;Ipatasertib; RG7440; GDC0068; GDC 0068; RG-7440; RG 7440;2s)-2-(4-chlorophenyl)-1-(4-((5r,7r)-6,7-dihydro-7-hydroxy-5-methyl-5h-cyclopentapyrimidin-4-yl)-1-piperazinyl)-3-((1-methylethyl)amino)-1-propanone