Everolimus

属性

溶解性	Soluble in chloroform, methanol, DMSO (100 mg/ml), water (<1 mg/ml at 25 °C), and ethanol (100 mg/ml).
存贮条件	储存温度-20°C

描述

应用	An immunosuppresive inhibitor of FRAP (mTOR).
产品介绍	Everolimus (RAD001)是一种mTOR抑制剂，作用于FKBP12，IC50为1.6-2.4 nM。
备注	Everolimus (RAD001) is an mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM.
生化机理	Everolimus is a macrolide derived from rapamycin with immunosuppressant properties shown to inhibit cell proliferation induced by growth factors. Macrolides belong to a group of antibiotics that bind to the 50S ribosomal subunit and inhibit protein synthesis. Studies indicate that everolimus is a mTOR (FRAP) inhibitor that displays high affinity toward the intracellular receptor FKBP12. Additionally, the Everolimus-FKBP12 complex decreases the activity of the S6K1 and 4EBP by binding to FRAP
别名	依维莫司;RAD001; SDZ-RAD; Certican; Zortress; Afinitor;RAD 001;40-O-(2-Hydroxyethyl)rapamycin; 42-O-(2-Hydroxy)ethyl Rapamycin