| 货号 | CAS号 |
|---|---|
| C127073-10mg | 885499-61-6 |
| C127073-1mg | 885499-61-6 |
| C127073-50mg | 885499-61-6 |
| C127073-5mg | 885499-61-6 |
| 溶解性 |
|
| 存贮条件 | 储存温度-20°C |
| 备注 | CCT128930 is a potent, ATP-competitive and selective inhibitor of Akt2 with IC50 of 6 nM, 28-fold greater selectivity for Akt2 than the closely related PKA kinase. |
| 生化机理 |
CCT128930 is a novel potent ATP-competitive, AKT inhibitor with an IC50 of 6 nM. CCT128930 prevents AKT activity in vitro and in vivo and induces marked antitumor responses. CCT128930 showed significantly antiproliferative activity and inhibited the phosphorylation of a range of AKT substrates in multiple tumor cell lines in vitro, consistent with AKT inhibition. CCT128930 caused a G1 arrest in PTEN-null U87MG human glioblastoma cells, in good agreement with AKT pathway blockade. |
| 别名 | 4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-amine;4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-amine |
