| 货号 | CAS号 |
|---|---|
| S129720-10mg | 264218-23-7 |
| S129720-1mg | 264218-23-7 |
| S129720-50mg | 264218-23-7 |
| 溶解性 |
|
| 存贮条件 | 储存温度-20°C |
| 产品介绍 | SB 415286 |
| 合法信息 | Sold for only research purposes |
| 备注 | SB415286 is a potent GSK3α inhibitor with IC50/Ki of 78 nM/31 nM with equally effective inhibition of GSK-3β. |
| 生化机理 |
SB 415286 is a potent and selective cell-permeable, ATP-competitive inhibitor of GSK3α with an IC50 value of 78 nM (similar potency for GSK3β) and a Ki value of 31 nM. 1 As a result of GSK3 inhibition, SB 415286 stimulates glycogen synthesis in the Chang human liver cell line with an EC50 value of 2.9 ?M. SB 415286 also protects primary neurons from death induced by the PI3-kinase pathway. |
| 别名 | 3-(3-chloro-4-hydroxyphenylamino)-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione;3-(3-chloro-4-hydroxyphenylamino)-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione |
