AZD5363

属性

溶解性	DMSO 86 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
存贮条件	储存温度-20°C

描述

产品介绍	AZD5363是各种AKT亚型抑制剂，IC50<10nM。
生化机理	AZD5363, a novel pyrrolopyrimidine-derived compound, inhibited all AKT isoforms with a potency of 10 nmol/L or less and inhibited phosphorylation of AKT substrates in cells with a potency of approximately 0.3 to 0.8 μmol/L. AZD5363 monotherapy inhibited the proliferation of 41 of 182 solid and hematologic tumor cell lines with a potency of 3 μmol/L or less。
别名	AZD-5363;AZD 5363；4-氨基-N-((1S)-1-(4-氯苯基)-3-羟基丙基)-1-(7H-吡咯并(2,3-d)嘧啶-4-基)-4-哌啶甲酰胺;;AZD-5363;AZD 5363； 4-amino-n-((1s)-1-(4-chlorophenyl)-3-hydroxypropyl)-1-(7h-pyrrolo(2,3-d)pyrimidin-4-yl)-4-piperidinecarboxamide