MLN2238

属性

溶解性	DMSO 72 mg/mL Water <1 mg/mL Ethanol 9 mg/mL
存贮条件	储存温度-20°C

描述

产品介绍	MLN2238(Ixazomib)能抑制20S蛋白酶体的糜蛋白酶样蛋白水解位点(β5)，IC50和Ki分别为3.4 nM和0.93 nM。
生化机理	MLN2238 inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50 and Ki of 3.4 nM and 0.93 nM, respectively, also inhibits the caspase-like (β1) and trypsin-like (β2) proteolytic sites, with IC50 of 31 and 3500 nM. MLN2238 is a selective, potent, and reversible inhibitor of the proteasome in tumor cells. MLN2238 shows time-dependent reversible proteasome inhibition.
别名	MLN 2238;MLN-2238； B-[(1R)-1-[[2-[(2,5-二氯苯甲酰基)氨基]乙酰基]氨基]-3-甲基丁基]硼酸;Ixazomib;MLN 2238;MLN-2238； B-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]boronic acid