Tyrphostin AG 879

属性

沸点	~443.81° C at 760 mmHg
熔点	219-220° C
折光率	1.61
溶解性	DMSO 36 mg/mL Water <1 mg/mL Ethanol 3 mg/mL
存贮条件	储存温度-20°C

描述

应用	A protein tyrosine kinase inhibitor with potent effects on TrkA
产品介绍	AG879是酪氨酸激酶的抑制剂，能够抑制TrKA的磷酸化，但不能抑制TrKB 和TrKC，也是高选择性的ErbB2激酶抑制剂。
备注	Tyrphostin AG 879 potently inhibits HER2/ErbB2 with IC50 of 1 μM, 100- and 500-fold higher selective to ErbB2 than PDGFR and EGFR.
生化机理	Tyrphostin AG 879 is a protein tyrosine kinase inhibitor with potent effects on TrkA. This product reportedly inhibits NGF-induced PLC-γ 1 phosphorylation and phosphatidylinositol-3 kinase activation. Has been shown in lab studies to disrupt Sertoli cell aggregation and stop androgen-induced cell proliferation. AG 879 also displays anti-cancer effects by inhibiting the expression of RAF-1 gene encoding MAP kinase activity necessary for human breast cancer cell proliferation. Shown to inhibit Neu (HER-2 or ERBB2) expression and reduced tumor sizes in mice leukemia cells. Tyrphostin AG 879 is an inhibitor of Flk-1.
别名	AG 879；AG-879；AG879;AG 879；AG-879；AG879； α-Cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide； (E)-3-[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-cyano-2-propenethioamide