Tivantinib (ARQ 197)

属性

溶解性	DMSO 74 mg/mL Water <1 mg/mL Ethanol 40 mg/mL
存贮条件	储存温度-20°C

描述

备注	Tivantinib (ARQ 197) is the first non-ATP-competitive c-Met inhibitor with Ki of 0.355 μM, little activity to Ron, and no inhibition to EGFR, InsR, PDGFRα or FGFR1/4. Phase 3.
生化机理	Tivantinib is an orally available, small molecule inhibitor of the c-Met receptor tyrosine kinase.
别名	(3R,4R)-3-(2,3-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-6-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione;(3R,4R)-3-(2,3-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-6-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione