SGX-523

属性

溶解性	2 mg/mL in DMSO <1 mg/mL in Water <1 mg/mL in Ethanol
存贮条件	储存温度-20°C

描述

应用	A Met inhibitor
产品介绍	SGX-523是一种选择性的Met抑制剂，IC50为4 nM，对BRAFV599E， c-Raf， Abl和p38α无抑制活性。
备注	SGX-523 is a selective Met inhibitor with IC50 of 4 nM, no activity to BRAFV599E, c-Raf, Abl and p38α. Phase 1.
生化机理	SGX-523 is an exquisitely selective Met (receptor tyrosine kinase) inhibitor with an IC50 of 4 nM.
别名	SGX523; SGX 523; 6-[[6-(1-甲基-1H-吡唑-4-基)-1,2,4-三唑并[4,3-b]哒嗪-3-基]硫基]喹啉;SGX523; SGX 523;6-[[6-(1-Methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]thio]quinoline