Pazopanib HCl (GW786034 HCl)

属性

溶解性	Soluble in DMSO (17 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), and 30% PEG400/0.5% Tween80/5% propylene glycol (30 mg/ml at 25 °C).
存贮条件	储存温度-20°C

描述

应用	A multi-targeted inhibitor.
产品介绍	Pazopanib HCl (GW786034 HCl)是一种新型的针对VEGFR-1， VEGFR-2， VEGFR-3， PDGFR， FGFR， c-Kit和c-fms等多个靶点的抑制剂，IC50分别是10 nM， 30 nM， 47 nM， 84 nM， 74 nM， 140 nM和146 nM。
备注	Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM, respectively.Phase 2
生化机理	Pazopanib Hydrochloride (GW786034, Votrient, Armala) is a novel, multitargeted inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR, FGFR, c-Kit and c-fms with IC50 values of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM, respectively.
别名	GW786034;盐酸帕唑帕尼;GW786034; Votrient; Armala; GW 786034; GW-786034;Pazopanib hydrochloride