| 应用 |
A selective ATP-competitive Met inhibitor. |
| 产品介绍 |
PF-04217903是一种选择性的，ATP竞争性c-Met抑制剂，IC50为4.8 nM，对致癌基因突变型敏感(对Y1230C突变型没有活性)。 |
| 备注 |
PF******s a selective ATP-competitive c-Met inhibitor with IC50 of 4.8 nM, susceptible to oncogenic mutations (no activity to Y1230C mutant). Phase 1. |
| 生化机理 |
PF******s a selective ATP-competitive Met inhibitor (IC50 = 4.8 nM). |
| 别名 |
PF 04217903; 2-[4-[1-(喹啉-6-甲基)-1H-[1,2,3]三唑并[4,5-b]吡嗪-6-基]-1H-吡唑-1-基]乙醇;PF04217903;PF 04217903;2-{4-[1-(6-Quinolinylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl]-1H-pyrazol-1-yl}ethanol |
