| 应用 |
An inhibitor of IGF-1R autophosphorylation. |
| 产品介绍 |
PQ 401抑制IGF-1R区域自磷酸化，IC50为低于1 μM。 |
| 备注 |
PQ401 inhibits autophosphorylation of IGF-1R domain with IC50 of <1 μM. |
| 生化机理 |
PQ401 is a cell-permeable phenylquinolinyl-urea compound that inhibits IGF-1R autophosphorylation. The mechanism of inhibition likely involves indirect blocking of ATP binding. PQ401 also decreases IGF-1R-dependent tumor cell growth in vitro. |
| 别名 |
N-(5-氯-2-甲氧基苯基)-N'-(2-甲基-4-喹啉基)脲;PQ 401;PQ-401;IGF-1R Inhibitor II;N-(5-Chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)-urea |
