AP26113

属性

溶解性	DMSO 45 mg/mL Water <1 mg/mL Ethanol 106 mg/mL
存贮条件	储存温度-20°C

描述

产品介绍	AP26113是一种有效的ALK抑制剂，无细胞试验中IC50为0.62 nM，能够克服L1196M突变介导的Crizotinib耐药性。
备注	AP26113 is a potent ALK inhibitor with IC50 of 0.62 nM, demonstrated ability overcome Crizotinib resistance mediated by a L1196M mutation. Phase 1/2.
生化机理	AP26113 is a potent and selective active inhibitor of anaplastic lymphoma kinase(ALK) with IC50 of 0.62 nM.
别名	AP-26113; AP 26113;5-氯-N2-[4-[4-(二甲基氨基)-1-哌啶基]-2-甲氧基苯基]-N4-[2-(二甲基亚膦酰)苯基]-2,4-嘧啶二胺;AP-26113;AP 26113;5-Chloro-N2-[4-[4-(dimethylamino)-1-piperidinyl]-2-methoxyphenyl]-N4-[2-(dimethylphosphinyl)phenyl]-2,4-pyrimidinediamine