IWP-2

属性

沸点	723.12° C
熔点	316.82° C
溶解性	DMSO mg/mL Water mg/mL Ethanol mg/mL
存贮条件	储存温度2-8℃

描述

应用	An inhibitor of Wnt production
产品介绍	IWP-2 是Porcn功能钝化剂，IC50为27 nM，是Wnt生成抑制剂。
生化机理	IWP-2 is an inactivator of Porcn function; inhibitor of Wnt production. Wnt/b-catenin (‘canonical’) pathway maintains transcriptional programs that enable stem cells to remain multipotent. Hyperactivation of the Wnt/b-catenin pathway leads to disease stage. IWP-2 inhibits Wnt production. It appears that IWP inactivates Porcn function either by directly inhibiting the Porcn active site or by modulating the function of a Porcn regulator. Porcn is a member of the membrane-bound O-acyltransferase (MBOAT) family, which adds a palmitoyl group to Wnt proteins that is essential to their signaling ability and is required for Wnt secretion. IWP-2 is useful in both regenerative medicine and anticancer efforts.
别名	IWP 2; N-(6-甲基-2-苯并噻唑基)-2-((3,4,6,7-四氢-4-氧代-3-苯基噻吩并(3,2d)嘧啶-2-基)硫基)乙酰胺;;IWP 2; N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide