Vismodegib (GDC-0449)

属性

熔点	168-180 °C
溶解性	Soluble in DMSO (200 mg/ml), ethanol (10 mg/ml), and water (very poorly, maximum solubility in plain water is estimated to be about 10-20 μM buffers, serum, or other additives may increase or decrease the aqueous solubility).
存贮条件	储存温度-20°C

描述

应用	A potent hedgehog (Hh) signaling pathway inhibitor.
产品介绍	Vismodegib (GDC-0449)是一种有效的，新型的，特异性的hedgehog抑制剂，IC50为3 nM。GDC-0449也抑制P-gp作用，IC50为3.0μM。
备注	Vismodegib (GDC-0449) is a potent, novel and specific hedgehog inhibitor with IC50 of 3 nM and also inhibits P-gp with IC50 of 3.0 μM.
生化机理	Vismodegib is a potent hedgehog (Hh) signaling pathway inhibitor. Vismodegib is a potent inhibitor of two ABC transporters, ABCG2 and ABCB1/Mdr-1, with IC50 values of 1.4 and 3.0 μM, respectively. Vismodegib may have antitumor activity in locally advanced or metastatic basal-cell carcinoma.
别名	GDC-0449; GDC 0449; GDC0449;2-氯-N-[4-氯-3-(2-吡啶基)苯基]-4-(甲磺酰基)苯甲酰胺;GDC-0449;GDC 0449;GDC0449;HhAntag691; 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide