| 应用 |
尿激酶是一种蛋白酶,切割纤维蛋白溶酶原(plasminogen)形成纤溶酶(plasmin)。它结合到细胞表面受体（uPAR）,调节细胞粘附组织改建和迁移，同时也激活细胞内信号转导通路。尿激酶是由三部分域组成：同源于表皮生长因子（epidermal growth factor）的氨基末端域，是通过中央kringle域结合到羧基末端的蛋白酶域。 |
| 产品介绍 |
为人尿或肾细胞的蛋白水解酶。天然底物是纤溶酶原。对湿敏感。溶于水。干粉在4℃较稳定，水溶液在4℃的稳定期为3天。
Physical form
Lyophilized from 1 mL of 50 mM Tris-HCl, pH 7.4 with 100 mM NaCl, 0.1% PEG 6000, and 200 mM mannitol
Physical properties
High molecular weight form migrating at 54 kDa by SDS-PAGE under non-reducing conditions |
| 备注 |
Unit Definition
One unit will activate that amount of plasminogen which will produce a ΔA275 of 1.0 per ml per minute at pH 7.5 at 37 °C, when measuring perchloric acid soluble products from α-casein (1 cm light path). |
| 生化机理 |
Urokinase expression and invasiveness suppression by urinary trypsin inhibitor acts through MEK/ERK/c-Jun-dependent signaling pathways |
| 别名 |
U-血纤维蛋白溶酶原激活剂;Urokinase plasminogen activator;u-Plasminogen activator;Urokinase from human kidney cells |
