| 应用 |
It was used to study oxysterol-induced apoptosis in human endothelial cells |
| 产品介绍 |
7β-Hydroxy Cholesterol is a metabolite of Cholesterol. Its membrane organizing properties may have implications in Altzheimer’s disease. |
| 生化机理 |
7β-Hydroxycholesterol is an oxysterol, the enzymatic or non-enzymatic product of cholesterol oxidation. Oxysterols are cytotoxic and induce death in monocytes, smooth muscle cells and endothelial cells. The mechanism of apoptosis induced by oxysterols may involve caspases or DNA fragmentation. Increased levels of 7β-Hydroxycholesterol correlates with increased risk of cardiovascular diseases including atherosclerosis |
| 别名 |
7β-羟基胆固醇； 5--胆甾烯-3β,7β-二醇;5-Cholestene-3β,7β-diol;1H-cyclopenta[a]phenanthrene-3,7-diol |
