生化机理 |
Biological responses to LPA: 1.Cell Proliferation 2.Inhibition of differentiation (neuroblastoma cells, myoblasts) 3.Platelet aggregation 4.Smooth muscle contraction 5.Neurotransmitter release 6.Stress fibre formation/cell rounding/neurite retraction 7.Cell-surface-fibronectin binding 8.Tumor cell invasion 9.Chemotaxis (dictyostelium amoebae) 10.Cl--mediated membrane depolarization (fibroblasts) 11.Inhibition of connexin 43 based cell-cell communication 12.Increased tight junction permeability (brain endothelial cells) |