| 应用 |
2',3'-二脱氧胞苷 ;2,3-二脱氧胞嘧啶核苷 2',3'-二脱氧胞甙 双脱氧胞嘧啶核苷 2',3-双脱氧胞嘧啶核苷 扎西胞苷扎西他滨 ;2′,3′-Dideoxycytidine ;7481-89-2; C9H13N3O3 |
| 生化机理 |
Zalcitabine is a nucleoside analog reverse transcriptase inhibitor (NARTI). Zalcitabine is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Zalcitabine is phosphorylated in T cells and other HIV target cells into its active triphosphate form, ddCTP. This active metabolite works as a substrate for HIV reverse transcriptase, and also by incorporation into the viral DNA, hence terminating the chain elongation due to the missing hydroxyl group. Since Zalcitabine is a reverse transcriptase inhibitor it possess activity only against retroviruses. |
| 别名 |
2,3-二脱氧胞嘧啶核苷 ,2',3'-二脱氧胞甙 ,双脱氧胞嘧啶核苷 ,2',3-双脱氧胞嘧啶核苷 ,扎西胞苷,扎西他滨
;ddC,1-(2,3-Dideoxy-β-D-ribofuranosyl)cytosine,Zalcitabine |
