| 应用 |
胸苷和脱氧腺苷的类似物，能与dATP竞争结合并整合入DNA中，可抑制DNA合成。 |
| 产品介绍 |
Fludarabine is a purine analog included in the category of DNA-damaging drugs with well-known efficacy in B-cell chronic lymphocytic leukemia (B-CLL). |
| 生化机理 |
Fludarabine represses DNA replication and suppresses the nucleotide metabolism by inhibiting the enzyme ribonucleotide reductase. |
| 别名 |
氟达拉滨单磷酸盐;磷酸氟达拉滨;2-氟腺嘌呤9-β-D-阿糖腺苷5'-单磷酸盐;9-(β-D-阿糖腺苷)-2-氟腺嘌呤5'-单磷酸盐;2-F-ara-AMP;
Fludarabine monophosophate;
9-beta-D-Arabinofuranosyl-2-fluoroadenine-5'-monophosphate;
9-(β-D-Arabinofuranosyl)-2-fluoroadenine 5'-Monophosphate;
2-Fluoroadenine 9-β-D-Arabinofuranoside 5'-Monophosphate;
Fludarabine Monophosphate;
2-Fluoro-9-(5-O-phosphono-β-D-arabinofuranosyl)-9H-purin-6-amine |
