货号 | CAS号 |
---|---|
G111443-1g | 1953-04-4 |
G111443-500mg | 1953-04-4 |
G111443-100mg | 1953-04-4 |
熔点 | 256°C |
旋光率 | -95 ° (C=1.4, H2O) |
存贮条件 | 储存温度-20°C |
密度 | 1.8640 |
应用 | 胆碱酯酶抑制剂(Cholinesterase inhibitor),逆转东莨菪碱引起的失忆 |
生化机理 |
Galanthamine hydrobromide is a long-acting, centrally active acetylcholinesterase inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. Galanthamine hydrobromide prevents β-amyloid-induced apoptosis in SH-SY5Y and bovine chromaffin cells. Long-term administration reduces amyloid precursor protein deposition and neurodegeneration in a mouse model of Alzheimer's disease. |
别名 | Reminyl;6H-Benzofuro[3a,3,2-ef][2]benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, hydrobromideGalantamine hydrobromide |