| 应用 |
A benzodiazepine antagonist |
| 产品介绍 |
Flumazenil(Ro 15-1788)是非选择性含α1，α2，α3和α5 GABAA受体拮抗剂。 |
| 生化机理 |
Flumazenil, an imidazobenzodiazepine derivative, antagonizes the actions of benzodiazepines on the central nervous system. Flumazenil competitively inhibits the activity at the benzodiazepine recognition site on the GABA/benzodiazepine receptor complex. Flumazenil is a weak partial agonist in some animal models of activity, but has little or no agonist activity in humans. |
| 别名 |
Ro 15-1788; Ro15-1788;福马西尼;氟马泽尼;氟马西林;安易醒; 8-氟-5,6-二氢-5-甲基-6-氧代-4H-咪唑并[1,5-a][1,4]苯并二氮杂卓-3-甲酸乙酯;Anexate; Romazicon; Lanexat; Ethyl 8-fluoro-5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate |
