| 货号 | CAS号 |
|---|---|
| P120184-5mg | 952021-60-2 |
| P120184-25mg | 952021-60-2 |
| 存贮条件 | 储存温度2-8℃ |
| 应用 | PF-00477736是一个强有力的，有选择性的ATP竞争性的小分子抑制剂，抑制Chk1,此Chk1带有0.49 nM的Ki。该化合物废除DNA损伤诱导的细胞周期阻滞和提高临床重要的化疗药物的细胞毒性，包括吉西他滨和卡铂。 |
| 生化机理 |
PF 477736 is a CHK inhitor with Ki values of 0.49 and 47 nM for Chk1 and Chk2 respectively. A proprietary compound targeting cell cycle checkpoint kinase 1 (chk1) with potential chemopotentiation activity |
| 别名 | (alphaR)-alpha-氨基-N-(5,6-二氢-2-(1-甲基-1H-吡唑-4-基)-6-氧代-1H-吡咯并(4,3,2-ef)(2,3)苯并二氮杂卓-8-基)环己烷乙酰胺;(2R)-2-Amino-2-cyclohexyl-N-[2-(1-methyl-1H-pyrazol-4-yl)-6-oxo-5,6-dihydro-1H-[1,2]diazepino[4,5,6-cd]indol-8-yl]-acetamide PF******alphar)-alpha-amino-n-(5,6-dihydro-2-(1-methyl-1h-pyrazol-4-yl)-6-oxo-1h-pyrrolo(4,3,2-ef)(2,3)benzodiazepin-8-yl)cyclohexaneacetamide |
