| 货号 | CAS号 |
|---|---|
| P120182-5mg | 870653-45-5 |
| P120182-25mg | 870653-45-5 |
| 敏感性 | 对光敏感 |
| 存贮条件 | 储存温度 2-8°C，避光保存 |
| 应用 | Kv1.3钾离子通道的选择性抑制剂。 |
| 生化机理 |
PAP-1 is selective inhibitor of Kv1.3, voltage-gated K+ channel. PAP-1 (EC50=2 nM) potently inhibits human T effector memory cell proliferation and delayed hypersensitivity. Effective orally or intraperitoneally. 5-(4-Phenoxybutoxy)psoralen has 23-fold selectivity for Kv1.3 over Kv1.5, and 33-125-fold selectivity over other Kv1 family channels. In treatment of multiple sclerosis |
| 别名 | 4-(4-苯氧基丁氧基)-7H-呋喃并(3,2-g)(1)苯并吡喃-7-酮;PAP-1；Kv1.3抑制剂;PAP-1; 5-(4-phenoxybutoxy)psoralen;4-(4-phenoxybutoxy)-7h-furo(3,2-g)(1)benzopyran-7-one |
