| 货号 | CAS号 |
|---|---|
| N159149-1G | 6953-61-3 |
| N159149-250mg | 6953-61-3 |
| N159149-50mg | 6953-61-3 |
| 溶解性 | DMSO: ≥5 mg/mL |
| 生化机理 | 1-Naphthohydroxamic Acid is a cell-permeable, potent, and selective histone deacetylase 8 (HDAC8) inhibitor. 1-Naphthohydroxamic acid selectively inhibits HDAC8 (IC50 = 14 μM) over class I HDAC1 and class II HDAC6 (IC50 >100 μM). Treatment of cells with 1-Naphthohydroxamic acid does not increase neither global histone H4 nor tubulin acetylation . Also in contrast to the pan-HDAC inhibitors the compound is not reducing total intracellular HDAC activity. |
| 别名 | α-萘羟肟酸;N-Hydroxynaphthalene-1-carboxamide；a-Naphthohydroxamic acid |
