| 应用 |
抑制癌变。已被证明抑制动物的癌变。发现于十字花科蔬菜中发现。
Indole-3-carbinol has been used for encapsulation with poly-lactic-co-glycolic acid (PLGA), to study its in-vitro anti-cancerogenic effects on breast adenocarcinoma epithelial (MCF7), colon adenocarcinoma epithelial (Caco2), prostate carcinoma epithelial (PC3) cells. It has also been used as a cytochrome P4501A (CYP1A) inducer. |
| 产品介绍 |
Indole-3-carbinol is a novel secondary plant metabolite produced in cruciferous vegetables, such as cabbage, cauliflower and brussels sprouts. |
| 生化机理 |
Indole-3-carbinol (I3C) activates aryl hydrocarbon receptor (AhR) and induces G1 cell cycle arrest and apoptosis. Thus, it acts as a potential anti-cancer agent. In addition, it induces estradiol metabolism by stimulating cytochrome P450 enzymes.Therefore, I3C is considered to be a potent chemotherapeutic for various types of cancer including, breast,prostate, colon cancer, and leukemia. |
| 别名 |
3-吲哚甲醇 ;吲哚-3-甲醇;3-(羟甲基)吲哚;;3-(Hydroxymethyl)indole;3-Indolemethanol; |
