黄芩素
面议
细胞裂解和提取物

黄芩素

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上海阿拉丁生化科技股份有限公司
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产品特点
规格信息
货号 CAS号 价格
B107324-100g 491-67-8 面议
B107324-100mg 491-67-8 面议
B107324-1g 491-67-8 面议
B107324-25g 491-67-8 面议
B107324-5g 491-67-8 面议
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产品描述

属性

熔点 256-271°C
敏感性 对光和热敏感
溶解性 Soluble in alcohol, methanol, ether, acetone, ethyl acetate, hot glacial acetic acid, dilute sodium hydroxide, and DMSO (50 mM). Insoluble in water
存贮条件 储存温度2-8℃
密度 1.5480

描述

应用 An inhibitor of Ca2+ uptake, 5-LO, and 12-LO
产品介绍 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis, that inhibits cellular Ca2+ uptake, calcium mobilization, and adjuvant-induced arthritis. Baicalein has been shown to inhibit platelet 5-LO (5-lipoxygenase) (IC50=9.5 mM) and 12-LO (12-lipoxygenases) (IC50=0.12 mM) and reverse transcriptase. Baicalein reduces leukotriene biosynthesis and inhibits the release of lysosomal enzymes. Baicalein is a potent anti-inflammatory and anti-tumor agent, and it blocks PREP (prolyl oligopeptidase). Baicalein induces the S-phase arrest and apoptosis in proliferation of human lung squamous carcinoma CH27 cells. The declining expression of cdk1, cdk2, cyclin D2 and cyclin A by Baicalein resulted in the G1 and G2 cell cycle arrest in C6 rat glioma cells. Baicalein has anti-thrombotic, antiproliferative and anti-mitogenic effects. Baicalein inhibits protein tyrosine kinase in leukemia (CEM) cells and PMA-stimulated PKC (protein kinase C). Baicalein is an inhibitor of 15-LO and CYP2C9.
生化机理 中药类黄酮的组成成分,黄芩的主要黄酮,抑制花生四烯酸代谢中的12-脂肪氧化酶路径(12-lipoxygenase ,12-LOX),此路径能抑制癌细胞的增殖,诱导凋亡途径。
别名 三羟黄酮;黄芩苷元;黄芩黄素;黄芩甙元;5,6,7-三羟基黄酮;5,6,7-Trihydroxyflavone
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