| 应用 |
A heterobifunctional cross-linking reagent incorporating an extended spacer with amine and sulfhydryl reactivity. Typically coupled initially to molecules containing primary amine by amide bond buffered at pH 7.5 (6.5-8.5). The second coupling is specific for molecules containing free sulfhydryl by thioether linkage buffered at pH 6.8 (6.5-7.0). Useful for preparation of enzyme immunoconjugates and hapten carrier molecule conjugates. Contains 9 atom linker. An extended aliphatic spacer stabilizes the maleimide prior to coupling compared to aromatic spacers. |
| 产品介绍 |
4-（N-马来酰亚胺基甲基）环己烷羧酸 N-羟基琥珀酰亚胺酯（SMCC）是一种异双功能交联剂，其包含一个具有胺和巯基反应性的延长间隔基。[1]它通常首先通过酰胺键（pH7.5（6.5-8.5）缓冲）与含有伯胺的分子进行偶联。第二次偶联通过硫醚键（pH6.8（6.5-7.0）缓冲）与含有游离巯基的分子进行特异性偶联。SMCC包含九个原子连接子。与芳族间隔基相比，延伸的脂族间隔基可在偶联之前稳定马来酰亚胺。 |
| 别名 |
N-琥珀酰亚胺基4-(马来酰亚胺基甲基)环己烷羧酸酯;4-(N-Maleimidomethyl)cyclohexanecarboxylic Acid N-Succinimidyl Ester; SMCC |
