花生四烯酸甲酯

属性

沸点	403.94 °C at 760 mmHg
折光率	1.49
敏感性	对湿度敏感
溶解性	Soluble in heptane (10 mg/ml), ethanol, DMSO, DMF, and ethanol:PBS(pH 7.2)(1:1) (~0.5 mg/ml)
存贮条件	储存温度-20℃
密度	0.9000

描述

应用	The keystone essential fatty acid at the origin of the arachidonic acid cascade
产品介绍	Arachidonic Acid methyl ester is the keystone essential fatty acid at the origin of the arachidonic acid cascade. It is converted by cyclooxygenase, lipoxygenase, and epoxygenase enzymes into more than one hundred fifty different potent primary autacoid metabolites in species ranging from fungi to plants to mammals. Arachidonic acid is stored in tissue phospholipids in esterified form, where it comprises a small but critically controlled percentage of the polyunsaturated fatty acid pool. Arachidonic acid content is frequently measured by the saponification of the lipid fraction followed by methyl esterification and gas chromatographic analysis of the resulting FAME (fatty acid methyl ester) compounds. Arachidonic acid methyl ester can also be incorporated into dietary regimens or fed to cultured cells as a source of exogenous arachidonate.
生化机理	与大多数不饱和脂肪酸甲酯不同，花生四烯酸甲酯在 5 50 μM 时是蛋白激酶 C 的强效激活剂。在有效浓度范围的低端，因环加氧酶产物而产生作用，而脂氧合酶产物在较高浓度下介导效果。
别名	全顺式-5,8,11,14-二十碳四烯酸甲酯;Arachidonic Acid methyl ester;methyl all-cis-5,8,11,14-eicosatetraenoate;(5z,8z,11z,14z)-5,8,11,14-eicosatetraenoic acid methyl ester