| 应用 |
An antineoplastic agent that activates Chk 2 and cytochrome p450 |
| 产品介绍 |
3,3'-Diindolylmethane is an anticancer and antineoplastic agent. 3,3'-Diindolylmethane induces apoptosis in human cancer cells. 3,3'-Diindolylmethane is also an activator of CYP (cytochrome P450) and Chk2 (checkpoint kinase 2) as well as a partial agonist of aryl hydrocarbon receptor (Ah Receptor). The compound is a dimer of indole-3-carbinol. |
| 生化机理 |
Acid-catalyzed reaction product of a phytochemical naturally found in Brassicaceae, indole-3-carbinol.It functions as an antitumor agent. This derivative can both directly stimulate apoptosis at relatively high concentrations and sensitize TRAIL-induced apoptosis in human cancer cells.DIM induces a G1 cell cycle arrest in human breast cancer MCF-7 cells by a mechanism that includes increased expression of p21. DIM is a strong mitochondrial H+-ATPase inhibitor.The function of DIM and its derivatives as a new plant growth promoter has been studied in an eco-friendly system. |
| 别名 |
二(3,3'-吲哚基)甲烷;3,3'-二吲哚甲烷;DIM;Di-3-indolylmethane; Plant Indole; 3,3’-Methylenediindole;DIM |
