| 产品介绍 |
IBMX is a widely-used non-specific inhibitor of cyclic AMP (cAMP) and cyclic GMP (cGMP) phosphodiesterases (PDEs) (IC50 = 19, 50, 18, 13, 32, 7, and 50 μM for PDE1, PDE2, PDE3, PDE4, PDE5, PDE7, and PDE11, respectively). PDE8A, PDE8B, and PDE9 are insensitive to IBMX. By inhibiting PDEs, IBMX increases cellular cAMP and cGMP levels, activating cyclic-nucleotide-regulated protein kinases. Methylxanthines, including IBMX, caffeine, and theophylline, bind adenosine receptors,typically antagonizing the suppressive effects of natural agonists. |
| 别名 |
IBMX;
1-甲基-3-异丁基黄嘌呤;
3,7-二氢-1-甲基-3-(2-甲基丙基)-1H-嘌呤-2,6-二酮;
3-异丁基-1-甲基-2,6(1H,3H)-嘌呤二酮;
3-异丁基-1-甲基-2,6(1H,3H)-嘌呤二酮;1-Methyl-3-isobutylxanthine
3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione
3-Isobutyl-1-methyl-2,6(1H,3H)-purinedione
IBMX
MIX |
