| 货号 | CAS号 | 价格 |
|---|---|---|
| C111281-20mg | 7689-03-4 | ￥99.00 |
| 熔点 | 259-263°C |
| 存贮条件 | 贮存温度2-8℃ |
| 密度 | 1.5100 |
| 应用 | 不可逆转地的结合到DNA拓扑异构酶I复合物上，影响细胞周期进程 |
| 产品介绍 | 微溶于乙醇、氯仿，难溶于水。与酸不能生成稳定的盐，与氢氧化钠溶液加热反应可生成钠盐而溶于水。钠盐水溶液黄色澄明具蓝色荧光 |
| 生化机理 |
Camptothecin (CPT), a cytotoxic quinoline alkaloid, is a potent DNA enzyme topoisomerase I (topo I) inhibitor with an IC50 and IC70 of 50 nM and 0.225 μM for breast cancer cell line MDA-MB-231. It has recently been undergoing phase I clinical trials. In 3D fluorescence spectra, Camptothecin presented 3 fluorescence peaks with excitation wavelengths lambdaex of 215, 255 and 365 nm, separately. Camptothecin shows high activity against various tumor cells. |
| 别名 | 喜树碱;4-乙基-4-羟基-1H-吡喃[3'，4'：6，7]氮茚[1，2]喹啉-3，14(4H，12H)-二酮4-Ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione |
