| 货号 | CAS号 |
|---|---|
| P127143-250mg | 936563-96-1 |
| P127143-50mg | 936563-96-1 |
| P127143-5mg | 936563-96-1 |
| P127143-10mg | 936563-96-1 |
| 溶解性 | DMSO ≥85mg/mL Water <1.2mg/mL Ethanol ≥1.8mg/mL |
| 存贮条件 | 储存温度-20°C |
| 产品介绍 | Ibrutinib (PCI-32765)是一种有效的，高选择性的Btk抑制剂，IC50为0.5 nM，作用于Bmx， CSK， FGR， BRK及HCK，适度有效，对EGFR， Yes， ErbB2， JAK3等作用效果稍弱。 |
| 备注 | Ibrutinib is a potent and highly selective Btk inhibitor with IC50 of 0.5 nM, modestly potent to Bmx, CSK, FGR, BRK, HCK, less potent to EGFR, Yes, ErbB2, JAK3, etc. |
| 生化机理 |
PCI-32765 is a high potent irreversible BTK inhibitor with an IC50 of 0.46 nM for the purified Btk. |
| 别名 | PCI32765; 1-[(3R)-3-[4-氨基-3-(4-苯氧基苯基)-1H-吡唑并[3,4-d]嘧啶-1-基]-1-哌啶基]-2-丙烯-1-酮;Ibrutinib;PCI32765;PCI 32765;1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one |
