| 应用 |
A selective A(2A) antagonist used to study parkinson’s disease in vitro |
| 产品介绍 |
Istradefylline(KW6002)是口服活性的腺苷A2A受体拮抗剂，Ki为2.2 nM。 |
| 备注 |
Istradefylline is a selective adenosine A2A receptor (A2AR) antagonist with Ki of 2.2 nM. |
| 生化机理 |
Istradefylline is a very potent, selective and orally active adenosine A2A receptor antagonist in experimental models of Parkinson's disease. Istradefylline reduces dyskinesia resulting from long-term treatment with classical antiparkinson drugs such as levodopa. Istradefylline is an analog of caffeine. |
| 别名 |
8-((E)-2-(3,4-二甲氧基苯基)乙烯基)-1,3-二乙基-7-甲基嘌呤-2,6-二酮;;KW 6002;KW-6002;KW6002;istradefylline;8-((e)-2-(3,4-dimethoxyphenyl)ethenyl)-1,3-diethyl-7-methylpurine-2,6-dione; |
