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Note: no information is available on CDw145, CD181, CD182, CD185-194, CD196-199, CD211, CD214-216, CD218-220, CD237
CD: cluster designation of monoclonal antibodies (clusters of differentiation)
Designated at the 1st to 7th Workshops on International Human Leukocyte Differentiation Antigens
The last conference was in 2000. The next conference is in 2004.
HLDA Workshops are the primary mechanism to characterize leukocyte surface antigenic molecules and epies; erythroid antigens are now included
For 1st to 6th workshops, antibodies were submitted to the organizing laboratory, coded and sent to participating laboratories for testing against various cell types. For the 7th workshop, a CD designation could be established for a molecule if its gene has been cloned and at least one specific monoclonal antibody had been studied in the Workshop
Interpretation should be based on cellular distribution of staining, proportion of positively stained cells, staining intensity and cutoff levels.
Family of non-polymorphic MHC class I-like glycoproteins
Also member of immunoglobulin superfamily
On chromosome 1q22-23 (not MHC linked)
Has 5 different subsets, all noncovalently associated with 12 kd beta 2 microglobulin
Function: restrict T cell responses to certain antigens; may mediate thymic T cell development
Positive staining (normal): cortical thymocytes (70%), activated T cells, Langerhans cells, interdigitating dendritic cells
Positive staining (disease): pre T ALL with cortical thymocyte phenotype; Langerhans cell histiocytosis
Negative staining: mature peripheral T cells
Positive staining (normal): Dendritic cells in dermis/epidermis of benign inflammatory skin disorders
Positive staining (disease): Langerhans cell histiocytosis (fairly specific), myeloid leukemias, some B cell malignancies; dendritic cells in most peripheral cutaneous T cell lymphomas, AJCP 2001;116:72
Negative staining: normal B cells, most cutaneous peripheral B cell lymphomas (? reflects replacement of reactive pattern containing dendritic cells with a neoplastic pattern of B cells)
Micro images: Langerhans cell histiocytosis
Micro images (AJSP subscribers): pulmonary Langerhans cell histiocytosis
Micro images (Hum Path subscribers): Langerhans cell histiocytosis
References: AJSP 2001;25:630
Positive staining (disease): myeloid leukemias and some B cell malignancies
Negative staining: normal B cells
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