Physical interactions between intergrin alpha4beta1 heterodimer expressed on B cells and counter receptors on stroma cells are key mediators of the survival of normal and malignant B cells. Recent data indicate that integrin stimulation increases FBI-1, XIAP, surviving, and CCT4 expression but inhibits Requiem, c-Fos, and caspase 3 and 7 induction.

Contributor: Roger Anderson, PhD

REFERENCES: Astier AL et al. Temporal gene expression profile of human precursor B Leukemia cells induced by adhesion receptor: identification of pathways regulating B-cell survival. Blood. 2003;101:1118-1127