14.1. Peak areas in analytical chromatograms should be accurately and consistently integrated in a scientifically sound manner.
分析色谱中的峰面积积分应准确一致、科学合理。
14.2. Where possible, HPLC and GC instruments should be interfaced with computerised chromatographic data capturing and processing systems which are capable of performing the integration process automatically.
如果可能，HPLC和GC仪器应与能自动进行积分处理的计算机化色谱数据采集和处理系统设置接口。
14.3. The same integration parameters shouldbe applied to all peaks in a sample set or sample sequence unless otherwise scientifically justifiable.
除另有科学论证外，同一样品序列或样品序列中的所有峰均应使用相同的积分参数。
14.4. Personnel should select appropriate values for the parameters (such as, slope sensitivity, noise threshold, peak width, area threshold and bunching factor and skim ratio) which are used by the processing software to define the respective chromatographic peaks.
应选择适当的参数值（如斜率灵敏度、噪声阈值、峰宽、峰面积阈值和集束因子及撇去比率）在处理软件中定义相应的色谱峰。
14.5. To facilitate the accurate integration of chromatographic peaks, it is necessary that all of the peaks are fully separated. If quantitative data must be obtained from unseparated peaks, the laboratory should have clear policies as to how such peaks should be integrated. This should include a description as to when it is acceptable to use different functions for integrating unresolved peaks, such as:
为便于对色谱峰进行准确积分，有必要将所有峰完全分离。如果必须从未分开的峰中获得定量数据，则实验室应制订明确的方针说明如何对这些峰进行积分。其中应包括阐明何时可使用不同函数对未分离的峰进行积分，如：
• tangential skim;
• 切线撇去
• exponential skim;
• 指数撇去
• exponential curve fitting;
• 指数曲线设置
• straight line skim;
• 直线撇去
• front peak skim;
• 前伸峰撇去
• rear peak skim;
• 拖尾峰撇去
• peak valley ratio; and
• 峰谷比
• valley height ratio.
• 峰高比
14.6. Validated methods, specified chromatographic conditions and good chromatography practices should facilitate obtaining symmetrical peaks. Where fronting, tailing, split peaks or other types of peaks are observed, these should be investigated, the root cause identified and appropriate CAPA taken.
经过验证的方法、具体的色谱条件和优良色谱规范有助于获得对称峰。如果发现有前伸峰、拖尾峰、分裂峰或其它类型的峰，应进行调查，找出根本原因并采取适当的CAPA。
14.7. Where manual integration has to be done, authorized procedures should be followed. Records should be maintained which include the authorization and justification for manual integration.
如果必须进行手动积分，则应遵守经过批准的程序。应保存记录，其中包括手动积分的批准和理由。
14.8. Using a procedure to integrate peak height or area by manually setting the baseline using chromatographic software should only be allowed in exceptional cases. Only a selected number of users should be granted privileges to do so. Records and justification should be given when this procedure is followed.
只有例外情形下，才可使用程序在利用色谱软件进行手动基线设置后对峰高或峰面积积分。
14.9. Where smoothing is applied, the typeof “filter” used and extent of smoothing should be justified.
如果做了平滑处理，所用“筛选”类型和平滑处理的程度应进行论证。
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