Perspectives

    Obesity is closely associated with hypertension. The mechanisms underlying hypertension in obesity, however, have not been fully clarified. Adiponectin has many defensive properties against obesity-related diseases, such as type 2 diabetes and coronary artery disease. In the present study, we demonstrated for the first time that adiponectin treatment lowers obesity-related hypertension. Therefore, adiponectin treatment is potentially useful for hypertension and may help in establishing a unified approach for the treatment of the metabolic syndrome.

    Acknowledgments

    This work was supported in part by a Grant-in-Aid for Scientific Research (B) No. 14370327, Grants-in-Aid for Scientific Research on Priority Areas No. 13137206 and 15081208, Grant-in-Aid for Scientific Research (B) No. 15390287, Takeda Science Foundation, the Research Fellowships of the Japan Society for the Promotion of Science for Young Scientists, Mitsubishi Pharma Research Foundation, Yamanouchi Foundation for Research on Metabolic Disorders, The Cell Science Research Foundation, and Japan Heart Foundation Grant for Research on Arteriosclerosis Update. We gratefully acknowledge the technical assistance of Sachiyo Tanaka and Kaori Yamamoto.

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